Resistance to antimicrobials has emerged to be one of the greatest threats to health worldwide. The development of antimicrobial resistanc...
Resistance to antimicrobials has emerged to be one of the greatest threats to health worldwide.
The development of antimicrobial resistance occurs when pathogens (such as viruses, bacteria, fungi, or parasites) change in time and develop resistance to treatment options currently available.
In the end there is a pressing need to find new antimicrobial drugs to combat infections.
Researchers from the University of Portsmouth and the Naresuan and Pibulsongkram Rajabhat Universities in Thailand have recently studied the possible antibacterial properties of the chemical hydroquinine. It is located in the bark of many plants.
While hydroquinine was previously proven as a powerful treatment for human malaria, very little research has been conducted on its resistance to drugs until now.
The study, released in Tropical Medicine and Infectious Disease The study suggest that the organic chemical could be worthy of further research due to its antibacterial abilities.
"Using bacterial killing experiments," as described by Dr. Robert Baldock, "we discovered that hydroquinine is effective in killing several microorganisms, including the multidrug-resistant pathogen pseudomonas.
"Characteristically," the author added, "we also discovered that one of the main mechanisms used by these bacteria to escape killing activity of the drug was upregulated with treatment - indicating a robust response from the bacteria.
"By studying this compound further, our hope is that it may in future offer another line of treatment in combatting bacterial infections."
There are more than 2.8 million illnesses are caused by drug resistant bacteria, and they also result in 35,000 deaths each year. The most common "superbugs" resistant to antibiotics are the primary causes of infections like pneumonia UTIs Sepsis, UTIs and pneumonia.
According to research, P. aeruginosa bloodstream infections are associated with a high mortality rate that range from 30 to 50 percent.
The report suggests that further studies be conducted on the antimicrobial properties of hydroquinine and adverse consequences.
Its Department of Medical Technology at Naresuan University's Dr. Jirapas Jingjitwimol stated, "Our future research aims to determine the molecular target of hydroquinine. This will aid in understanding of the mechanism by which this compound acts against pathogenic bacteria, and what it might do to be utilized in a clinical setting."
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